A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50=<0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50=<100 μM).

1331754-16-5

C6H8N2O2

140.14

A6770

DMF:30 mg/mL
PBS (pH 7.2):10 mg/mL
DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years