ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfusion fluid in the field of neurosurgery, such as intracranial surgery, or when used as a replenishing fluid for lost cerebrospinal fluid. ACSF is also used to maintain pH balance and tissue oxygen delivery for research.

ACSF is often used to maintain oxygen supply in the study of basic characteristics of a neuronal function were acute in vitro brain slice models are required. When tested with neocortical mouse slices, carbonated ACSF treatment could keep pH balance and tissue oxygen delivery; otherwise, seizure-like events occurred in the slices with no-magnesium ACSF treatment [1].

In the study of targeted drugs to protect neurons, ACSF is often to treat the mice and worked as a control to calculate drug efficiency. It is also reported in the rat brain slice model, treated with ACSF, a replacement of human CSF, could powerfully boost spontaneous firing of CA1, CA3, and layer 5 pyramidal neurons [3][4].

T22551

C20H20N2O2

320.38

ACSF

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years