SR8278 是竞争性核血红素受体REV-ERB合成拮抗剂，能够抑制 REV-ERBα 转录活性(EC50:0.47 μM)。它可用于调节生物体内的代谢和研究生物节律。

SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112

SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells[1]

1254944-66-5

C18H19NO3S2

361.47

SR8278

DMSO:10mg/ml(27.66mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years