产品描述
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
体内活性
SK1-IN-1 shows significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.
Cas No.
1218816-71-7
分子式
C22H30N4O3
分子量
398.5
别名
SK1-IN-1
储存和溶解度
DMSO:100 mg/mL (250.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years