CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis:<0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.

CDK4/6-IN-3 inhibits MCF7 and BT549 cell lines proliferation (EC50s: 30 nM and 2.1 μM).

2366237-37-6

C25H31FN8

462.57

CDK4/6-IN-3

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years