(R)?-?CR8 是 ROScovitine 类似物，是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。

(R)-CR8 is a potent and selective CDK inhibitor.

A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA;?cortical, hippocampal, and thalamic neuronal loss;?and cortical microglial and astrocyte activation.?Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume[1].

294646-77-8

C24H29N7O

431.53

(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇;CR8;(R)-CR8;(R)-Isomer;(R)-CR8

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years