ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC?) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand PomalIDOmide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cellsin vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and Apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC(R)) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cellsin vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

2414418-49-6

C42H45N11O6

799.88

ZNL 02-096

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years