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Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat图片
CAS NO:149635-73-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
MOG (35-55)
髓鞘少突胶质细胞糖蛋白
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
产品介绍
MOG (35-55) 是中枢神经鞘的一个次要成分。它能诱导强效的 T细胞和 B 细胞反应,同时是高度脑源性的。它能够引发复发缓解性神经系统疾病,伴有广泛的斑块样脱髓鞘。

产品描述

MOG (35-55) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG).

体外活性

CD8CD3 and CD4CD3 cells were 86% and 94% pure of total CD3 cells after CD8/CD4 bead enrichment, respectively.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?Although the CD8 T cells had a generally lower response to MOG35-55 than CD4 T cells, the response of CD8 T cells was not always dependent on CD4.?CD8 T cell secreted less IFN-γ and IL-4 compared with CD4 T cells[1].

体内活性

EAE was induced in wildtype B6 na?ve mice by adoptive transfer of MOG35-55-specific T cells from B6 active-induced EAE (aEAE) mice.?A similar EAE score and slight inflammation and demyelination were found in naive B6 mice after transferring of CD8 T cells from immunized B6 mice compared with transfer of CD4 T cells[1].

动物实验

Female C57BL/6 mice (n?=?20) were induced by myelin oligodendrocyte glycoprotein (MOG)35-55 peptide.?At 14 days after immunization, T cells were isolated from the spleen and purified as CD4 and CD8 T cells by using CD4 and CD8 isolation kits, and then the purity was determined by flow cytometric analysis.?These cells were stimulated by MOG35-55 peptide and applied to proliferation assays.?The interferon-gamma (IFN-γ) and interleukin (IL)-4 secretion of supernatant of cultured CD4 and CD8 T cells were measured by enzyme-linked immunosorbent assays (ELISA).?For adoptive transfer, recipient mice were injected with MOG35-55-specific CD8 or CD4 T cells.?EAE clinical course was measured by EAE score at 0-5 scale and spinal cord was examined by staining with hematoxylin and eosin and Luxol fast blue staining[1].

Cas No.

149635-73-4

分子式

C118H177N35O29S

分子量

2581.99

别名

MOG (35-55);髓鞘少突胶质细胞糖蛋白;Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

储存和溶解度

H2O:Insoluble
DMSO:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years