EAI001 是一个有效的选择性突变体表皮生长因子受体 (EGFR) 变构抑制剂，抑制 EGFRL858R/T790M的IC50值为 24 nM。EAI001 可用于癌症研究。

EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC 50 value of 24 nM for EGFR L858R/T790M. EAI001 can be used for research of cancer [1] [2].

EAI001 (50 μM) binds to EGFR T790M/C797S/V948R that lies deep inside the EGFR towards the ATP binding site and C-helix. EAI001 showed inhibitory activity due to hydrophobic interaction with amino acid Ile759, Leu747, Leu788, Leu777 and Met766 [1].

892772-75-7

C19H15N3O2S

349.41

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years