VO-OHPic 是一种可逆的、非竞争性的、选择性的PTEN抑制剂，IC50为 46 nM。在 doxorubicin 诱导的心肌病中，VO-OHPic 可减少细胞凋亡 (Apoptosis)、不良的心脏重塑和促炎 M1 巨噬细胞。VO-OHPic 抑制细胞自噬 (Autophagy)。

VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC 50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy [1] [2] [3].

675848-25-6

C12H10N2O8V

361.16

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years