GSK2292767 是选择性的PI3Kδ的抑制剂，pIC50=10.1。它的选择性比其他 PI3K 亚型高的 500 倍以上。它可用于研究呼吸系统疾病。

GSK2292767 is a potent and selective PI3Kδ inhibitor.

BI-847325 shows growth-inhibitory effects on BRAF-mutant and vemurafenib-resistant melanoma cells with IC50 ranging from 0.3 nM to 2 μM, and prevents colony formation in six BRAF-mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression. [1]

GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation[1].

1254036-66-2

C24H28N6O5S

512.58

GSK2292767

DMSO:93 mg/mL (181.4 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years