740 Y-P(TFA)(1236188-16-1 free base) 是一种有效的细胞渗透性 PI3K 激活剂。

740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.

740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2].

TQ0003L

C143H223F3N43O41PS3

3384.73

PDGFR 740Y-P(TFA);740 Y-P(TFA);740YPDGFR(TFA);740 Y-P(TFA)(1236188-16-1 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years