TG100713 是一种PI3K的抑制剂，抑制PI3Kδ，γ，α和β的IC50值分别为24、50、165 和 215 nM。

TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.

TG 100713 also strongly inhibits EC proliferation. [1]

Kinase Assays: PI3K reactions are constructed by using recombinant human kinases, 3 μM ATP, phosphatidylinositol substrate, and cofactors, and reaction progression measured by using a luminescent-based detection system to quantify ATP consumption. Protein kinase assays are performed by using commercial screening services.

Human umbilical vein EC plated in 96-well cluster plates (5,000 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of test compounds (10 μM), and cell numbers are quantified by XTT assay.(Only for Reference)

925705-73-3

C12H10N6O

254.253

TG100713;TG 100713

DMSO:2.5 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years