IITZ-01 是一个具有抗肿瘤活性的亲溶酶体自噬抑制剂，其对 PI3Kγ 的IC50值为 2.62 μM。

IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)

IITZ-01 enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).?IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.

1807988-47-1

C26H23FN8O

482.523

IITZ-01

DMSO:150 mg/mL (310.87 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years