Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.

146764-24-1

C14H25NO5S

319.42

4-hydroxy Nonenal Mercapturic Acid

Ethanol:>50 mg/mL (per Ramki)
DMF:>50 mg/mL (per Ramki)
PBS (pH 7.2):>100 μg/mL (per Ramki)
DMSO:>50 mg/mL (per Ramki)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years