Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 , PGD2 , and TXB2 in peritoneal exudates.

1810710-59-8

C32H47N3O9S

649.79

PCTR1;PCTR1

Ethanol:H2O (95:5):2 mg/mL
Ethanol:1 mg/mL
DMSO:50 mg/mL
PBS (pH 7.2):0.1 mg/mL
DMF:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years