MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.

1101113-39-6

C32H42BrNO2P

583.56

MitoTEMPOL

DMF:50 mg/mL
DMSO:50 mg/mL
Ethanol:50 mg/mL
PBS (pH 7.2):10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years