TCMDC-135051 TFA is a highly selective and potent inhibitor of protein kinase PfCLK3.

In a liver invasion and development assay, TCMDC-135051 TFA shows potent activity against P. berghei sporozoites in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM) . The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 TFA has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively.

T13102L

C31H34F3N3O5

585.61

TCMDC-135051 TFA;TCMDC-135051 TFA (2413716-15-9 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years