OMDM-4 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 17.7 μM).

OMDM-4 is anovel potent and selective inhibitors of ACU?and one "hybrid" agonist of CB(1) and VR1 receptors (OMDM-6).?Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.OMDM-4 shows poor affinity for either CB1 (Ki=12.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively;?OMDM-4 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50≥10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM)[1].

616884-65-2

C29H43NO3

453.66

OMDM-4

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years