Oxythiamine is an antimetabolite and an antagonist of vitamin B1.

Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo.Annexin A1 expression was significantly down-regulated by OT treatment in time-dependent manner, while no change of this protein was observed in OT dose-dependent fashion.?Pathway analysis suggested that inhibition of transketolase resulted in changes of multiple cellular signaling pathways associated with cell apoptosis.

136-16-3

C12H16N3O2S

266.34

Hydroxythiamin;Oxythiamine

DMSO:51.67 mg/mL (194.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years