PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).

PF-00446687 has a relatively weak activity at the MC1, MC3, and MC5 receptors(EC50s of 1.02±0.30 μM, 1.16±0.35 μM, and 1.98±0.20 μM, respectively).

Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small molecule MC4R agonist, Pf-446687, enhances partner preference formation in the prairie vole, but not in the non-monogamous meadow vole[2].

862281-92-3

C28H36F2N2O2

470.59

PF-00446687

DMSO:62.5 mg/mL (132.81 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years