BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa; Kis: 0.2 and 0.42 nM for human and rabbit FXIa).

BMS-654457 shows comparable in vitro potency against FXIa and was over 500-fold selective against coagulation-related proteases (thrombin, FXa, and FVIIa) in these species.

BMS-654457 is potent in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time.

1004551-41-0

C36H37N5O4

603.71

BMS-654457

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years