ThalIDOmide-O-amIDO-PEG2-C2-NH2 TFA 包含基于 ThalIDOmide 的 cereblon 配体和 2 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG2-C2-NH2 TFA incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

1957235-75-4

C23H27F3N4O10

576.48

E3 Ligase Ligand-Linker Conjugates 24 TFA;Cereblon Ligand-Linker Conjugates 10 TFA;Thalidomide-O-amido-PEG2-C2-NH2 TFA

H2O:150 mg/mL (260.20 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years