c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

2230821-68-6

C58H65F2N7O11S

1106.24

SJF 8240

DMSO:55.31 mg/mL(50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years