NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].

NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].

941580-60-5

C20H26N4O3S

402.51

NVS-PI3-4;NVS-PI3-4

DMSO:250 mg/mL (621.10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years