DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity.

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC 50 >40 μM)[1].

2416022-90-5

C22H13F3N6O

434.382

DDR1-IN-5;DDR1-IN-5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years