DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity.

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =13 nM)[1]. DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC 50 =3 μM)[1]. DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC 50 =5.7 μM of 3 days; IC 50 =2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC 50 >30 μM of 3 days; IC 50 >30 μM of 6 days)[1].

2416021-47-9

C23H14F3N5O

433.394

DDR1-IN-6;DDR1-IN-6

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years