PI3Kδ-IN-1 是高效，选择性的 PI3Kδ 抑制剂，IC50 为 1.7 nM。

PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).

PI3Kδ-IN-1 has an improved human/rodent in vitro stability correlation and a good permeability profile[1].

PI3Kδ-IN-1 shows greater than 50% suppression of paw swelling in mice. PI3Kδ-IN-1 has an EC50 of 10 nM at 24 h (ED50 of ~1.25 mg/kg) in mice[1].

1911564-39-0

C22H20F3N7O2

471.44

PI3Kδ-IN-1

H2O:18.0 mg/mL (37.6 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years