BDP-13176 是fascin 1抑制剂,Kd=90 nM,IC50=240 nM。它具有成为抗转移剂的潜力。
产品描述
BDP-13176 is a potent inhibitor of fascin 1(Kd of 90 nM and an IC50 of 240 nM). It has potential as an anti-metastatic agent
体外活性
BDP-13176 (0-1 μM) inhibits fascin 1 bundling activity. Fascin is an actin binding and bundling protein that is not expressed in normal epithelial tissues but overexpressed in a variety of invasive epithelial tumors. It has a critical role in Cancer cell metastasis by promoting cell migration and invasion.
Cas No.
2290660-61-4
分子式
C24H22Cl2N6O2
分子量
497.38
别名
BDP-13176
储存和溶解度
DMSO:125 mg/mL (251.32 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years