您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Vutiglabridin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Vutiglabridin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1800188-47-9
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
Vutiglabridin (HSG4112) 是一种外消旋化合物,是一种有效的抗肥胖剂。Vutiglabridin 是光甘草定的优化结构类似物,在减重功效和化学稳定性方面具有优势。

产品描述

Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent [1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability [1].

体内活性

Vutiglabridin (HSG4112) fully reverses adiposity in HFD-induced obese mice in a dose-dependent manner. Vutiglabridin (orally administered with 10, 30, or 100 mg/kg dose for 6 weeks) dose-dependently reduces body weight and normalizes obesity-related parameters in high-fat diet (HFD)-induced obese mice [2]. Animal Model: HFD-induced obese male C57BL/6J mice [2] Dosage: 10, 30, and 100 mg/kg Administration: Orally administered for 6 weeks Result: Led to significant dose-dependent body weight reduction by 4.0 g (8.3%), 10 g (21%), and 19 g (40%), respectively, compared to the 48.1 g body weight of HFD-induced obese mice administered with only the vehicle at 10, 30, and 100 mg/kg.

Cas No.

1800188-47-9

分子式

C22H26O4

分子量

354.44

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years