PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

2379569-17-0

C30H55F3N8O9

728.812

PAR2 (1-6) amide (human) (trifluoroacetate salt);PAR2 (1-6) amide (human) (trifluoroacetate salt)

DMSO:15 mg/mL
Ethanol:5 mg/mL
DMF:30 mg/mL
PBS (pH 7.2):10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years