21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

641-77-0

C21H30O4

346.46

21-Deoxycortisol

Methanol:Slightly soluble
Chloroform:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years