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MHC class II antigen(45-57)[Homo sapiens]
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MHC class II antigen(45-57)[Homo sapiens]图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议

产品名称
MHC class II antigen (45-57) [Homo sapiens]
产品介绍

产品描述

MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and lymphocytes.

体外活性

The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in class I); hence, the MHC class II-dependent pathway of antigen presentation is called the endocytic or exogenous pathway. Loading of MHC class II occurs by phagocytosis; extracellular proteins are endocytosed, ingested in lysosomes, and created by the class II MHC molecule prior to the molecule's migration to the cellular membrane. MHC class two is formed of two chains, α, and β, each having two domains—α1 and α2 and β1 and β2—each chain having a transmembrane domain, α2, and β2, respectively, anchoring the MHC class II molecule to the cell membrane. The peptide-binding groove is formed of the heterodimer of α1 and β1.MHC class II molecules in humans have five to six isotypes. Classic molecules present peptides to CD4+ lymphocytes. Nonclassic molecules, accessories, with intracellular functions, are not exposed on cell membranes, but in internal membranes in lysosomes, normally loading the antigenic peptides onto classic MHC class II molecules[1][2].

Cas No.

TP2270

分子式

C73H112N18O25

分子量

1641.78

别名

MHC class II antigen (45-57) [Homo sapiens]

储存和溶解度

DMSO:≥164.2mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years