ERα degrader 5 (Compound 40) 是一种选择性的、具有口服活性的雌激素受体 (estrogen receptor (ER)) 降解剂，对 ERα 的EC50值为 1.1 nM。ERα degrader 5 在体内表现出抗肿瘤活性。

ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC 50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo [1].

ERα degrader 5 (Compound 40) shows antiproliferative activity with an IC 50 of 1.0 nM against MCF-7 [1].

C29H25F4N3O2S

555.59

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years