| CAS NO: | 50-41-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 100g | 电议 |
| Molecular Weight (MW) | 598.08 |
|---|---|
| Formula | C26H28ClNO.C6H8O7 |
| CAS No. | 50-41-9 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 120 mg/mL (200.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: 11 mg/mL (18.4 mM) | |
| Solubility (In vivo) | Chemical Name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine InChi Key: GKIRPKYJQBWNGO-QPLCGJKRSA-N InChi Code: InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25- SMILES Code: CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3 |
| Synonyms | NSC-35770; Clomiphene; D; Chloramiphene; NSC35770; NSC 35770; Omifin; Citrate; Clomiphene; Clomide; Clomifen; Clostilbegit; Clomid; Androxal; Dyneric; Gravosan; Klostilbegit; Serophene |
| In Vitro | In vitro activity: Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene). |
|---|---|
| In Vivo | Clomiphene citrate treatment significantly increases the chance of homosexuality and effeminized behavior in male mice. |
| Animal model | Mice |
| Formulation & Dosage | |
| References | Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92. |
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