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Clomifene citrate(Clomiphene)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clomifene citrate(Clomiphene)图片
CAS NO:50-41-9
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)598.08
FormulaC26H28ClNO.C6H8O7
CAS No.50-41-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 120 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: 11 mg/mL (18.4 mM)
Solubility (In vivo)

Chemical Name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine

InChi Key: GKIRPKYJQBWNGO-QPLCGJKRSA-N

InChi Code: InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25-

SMILES Code: CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3

SynonymsNSC-35770; Clomiphene; D; Chloramiphene; NSC35770; NSC 35770; Omifin; Citrate; Clomiphene; Clomide; Clomifen; Clostilbegit; Clomid; Androxal; Dyneric; Gravosan; Klostilbegit; Serophene
实验参考方法
In Vitro

In vitro activity: Clomifene competes with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropinrelease, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomifene is a mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene).

In VivoClomiphene citrate treatment significantly increases the chance of homosexuality and effeminized behavior in male mice.
Animal modelMice
Formulation & Dosage
References

Cancer Chemother Pharmacol. 1990;26(4):310-2; Dongwuxue Yanjiu. 2013 Oct;34(5):487-92.