ZIKV-IN-2 (compound 3a) 是一种有效的 ZIKV NS5 甲基转移酶 (MTase) 抑制剂，其IC50值为 38.86 μM。ZIKV-IN-2 抑制 ZIKV 的复制和感染。ZIKV-IN-2 可用于寨卡病毒 (ZIKV) 的研究。

ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC 50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV) [1].

ZIKV-IN-2 (compound 3a; 0.08-50 μM) inhibits the expression of ZIKV E protein with an EC 50 value of 6.17 μM and inhibits ZIKV replication and infection [1]. ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells [1]. Cell Viability Assay [1] Cell Line: Vero, Huh7 and A549 cells Concentration: 0.08, 0.4, 2, 10, and 50 μM Incubation Time: 96 hours Result: Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC 50 >200 μM to all three cell lines.

910582-16-0

C39H42O4

574.75

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years