ZIKV-IN-1 是一种有效的zika virus抑制剂，EC50为 2.8 μM，EC90为 6.8 μM。ZIKV-IN-1 显示出抗 ZIKV 活性，且具有低细胞毒性。ZIKV-IN-1 对 ZIKV RdRp 结构域具有很强的亲和力。

ZIKV-IN-1 is a potent zika virus inhibitor with an EC 50 of 2.8 μM and EC 90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain [1].

ZIKV-IN-1 (compound 38) (0-80 μM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells [1]. ZIKV-IN-1 (5, 10, 25 μM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein [1]. ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 μM; 0-250 s) shows strong affinity to ZIKV RdRp domain (K d =1.87 μM) in A549 cells [1]. Cell Viability Assay [1] Cell Line: A549 cells Concentration: 0-50 μM Incubation Time: Result: Showed anti-ZIKV activity with an EC 50 of 2.8 μM, EC 90 of 6.8 μM, and CC 50 of >50 μM. Western Blot Analysis [1] Cell Line: A549, Vero cells Concentration: 5, 10, 25 μM Incubation Time: 48 h Result: Decreased the expression of ZIKV E and cleaved caspase 3 protein. Cell Cytotoxicity Assay [1] Cell Line: Vero, SNB19, Huh7, A549 cells Concentration: 0-80 μM Incubation Time: Result: Showed low cytotoxicity with CC 50 s of 46.8, 49.4, 43.8, 54.1 μM for ZG01 strain of Vero, SNB19, Huh7, A549 cells, and CC 50 s of 470.5, 485.2, 512.8, 160.8 μM for MR766 strain of Vero, SNB19, Huh7, A549 cells, respectively.

2762166-06-1

C21H18BrF2N3O3

478.29

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years