Ethambutol dihydrochloride能抗分枝杆菌，可抑制阿拉伯糖基转移酶活性来阻止细胞壁形成。

Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

在动物模型中,Ethambutol通过口服方式给药,剂量是100 mg/kg.

Ethambutol的主要作用靶点是embB基因产物,在肺结核耐药株中,Ethambutol促使emb基因突变。耻垢分枝杆菌中,Ethambutol作用于阿拉伯半乳聚糖和脂阿拉伯甘露聚糖。

1070-11-7

C10H26Cl2N2O2

277.23

盐酸乙胺丁醇;CL40881;Ethambutol 2HCl;Emb dihydrochloride;Ethambutol dihydrochloride

Ethanol:<1 mgml
H2O:51 mg/mL (184 mM)
DMSO:52 mg/mL (187.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years