Tedizolid phosphate 是MAO-A和MAO-B抑制剂，具有抗革兰氏阳性菌的活性。

Tedizolid is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.

Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA)[2]. Tedizolid is 4-fold more potent than linezolid against PRSP isolates in vitro[1].

Tedizolid has excellent penetration into pulmonary epithelial lining fluid (ELF). Tedizolid phosphate administered to mice orally or intravenously is effective in vivo against systemic infection with PRSP isolates. Oral tedizolid phosphate is also effective in vivo against pneumonia induced with a PSSP strain[1].

856867-55-5

C17H16FN6O6P

450.323

磷酸特地唑胺;TR-701FA;Torezolid phosphate;Tedizolid Phosphate

H2O:<1 mgml
DMSO:21 mg/mL (46.6 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years