BLI-489 hydrate 是一种青霉烯类 β-内酰胺酶抑制剂，对 A 类和 C 类以及一些 D 类 β-内酰胺酶具有活性。Piperacillin 与 BLI-489 hydrate 联用对 A 类 (包括超广谱 β-内酰胺酶)、C 类 (AmpC) 和 D 类 β-内酰胺酶表达病原体引起的小鼠感染有效。

BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens [1] [2].

On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens [2].

C13H12N3NaO5S

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years