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Methoctramine(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methoctramine(hydrate)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议

产品名称
Methoctramine (hydrate)
产品介绍

产品描述

Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively).

体外活性

In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2]

体内活性

In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs with ED50 values of 38 and 81 nmol/kg, respectively. In a rat model of spinal cord injury, methoctramine suppresses bladder overactivity induced by the non-selective muscarinic acetylcholine receptor agonist oxotremorine M.[3]

别名

Methoctramine (hydrate)

储存和溶解度

PBS (pH 7.2):10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years