CB-6644 是RUVBL1/2的选择性复合体抑制剂，能够抑制 RUVBL1/2 的 ATP 酶活性(IC50:15 nM)。它具有抗癌作用。

CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).

CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).

CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

2316817-88-4

C29H34ClFN4O5

573.06

CB-6644

DMSO:88 mg/mL (153.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years