Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.

CRBN-6-5-5-VHL

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years