CCG-271423 是一种有效的选择性GRK5抑制剂，GRK5 和 GRK2 的IC50值分别为 0.0021 μM 和 44 μM。CCG-271423 抑制心肌细胞收缩能力，降低 Ca2+瞬态。

CCG-271423 is a potent and selective GRK5 inhibitor with IC 50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca 2+ transience [1].

CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca 2+ transience [1].

2750413-88-6

C28H26N4O3

466.53

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years