Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.

70967-90-7

C27H38N6O9

590.63

MeOSuc-AAPV-pNA

PBS (pH 7.2):25 mg/mL
DMF:2 mg/mL
Ethanol:25 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years