AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A. AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it. AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal (IC50: 0.28 μM). AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal.

2387510-84-9

C15H9BrO5

349.13

AM12

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years