DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.

794494-38-5

C35H63N2O3

559.899

DMHAPC-Chol

DMF:10 mg/mL
Ethanol:PBS (pH 7.2) (1:6):0.14 mg/mL
Ethanol:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years