A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Derivative tertiapin LQ also available.

910044-56-3

C106H175N35O24S4

2452

Tertiapin-Q

H2O:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years