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(S)-Carvedilol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-Carvedilol图片
CAS NO:95094-00-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议

产品名称
(S)-卡维地洛
(S)-BM 14190
产品介绍

产品描述

(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

体外活性

(S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol in β-receptor blocking activity, whereas both enantiomers show equipotent potency as α-blockers. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro.

Cas No.

95094-00-1

分子式

C24H26N2O4

分子量

406.47

别名

(S)-卡维地洛;(S)-BM 14190;(S)-Carvedilol

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years