LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays).

2375720-38-8

C54H58N8O6

915.09

LH1307

DMF:25 mg/mL
DMSO:25 mg/mL
DMSO:PBS (pH 7.2) (1:2):0.3 mg/mL
Ethanol:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years